Peer-reviewed Research Publication:

1. 1. Chen YC, Bullock B, Ogbeh DI, Ai J, Okoh J, Liu J, Qiang Y, Hsia SV. In Vitro Modeling of Human Dorsal Root Ganglion Neurons for GCaMP6-Based Calcium Imaging of Sensory Responses to HSV-1 Infection. J Virol Methods. (2025) Sep 11:115264. doi: 10.1016/j.jviromet.(2025).115264. Epub ahead of print. PMID: 40945539.

   2. Zhang Q, Hsia SV, Martin-Caraballo,M. Regulation of voltage-gated sodium channels by TNF-α during herpes simplex virus latency establishment. J Neurochemistry. Oct. (2024) https://doi.org/10.1007/s13365-024-01229-4

   3. Osinaga FO, Chen YC, Kharel MK, Waguespack Y, Li S, Hsia SV. Early Events after Herpes Simplex Virus-Type 1 Entry Are Necessary for the Release of Gamma-Hydroxybutyrate upon Acute Infection. Pharmaceuticals 10 Aug (2023); 16(8): https://doi.org/10.3390/ph16081104

   4. Chen YC, Li H, Martin-Caraballo M, Hsia SV. Establishing a Herpesvirus Quiescent Infection in Differentiated Human Dorsal Root Ganglion Neuronal Cell Line Mediated by Micro-RNA Overexpression.  Pathogens. (2022) doi: 10.3390/pathogens11070803; PMCID: PMC9317301

   5. Osinaga FO, Blakeslee K, Kharel MK, Waguespack Y, Hsia SV. Method validation of gamma-Hydroxybutyric acid detection upon Herpes Simplex Virus-Type 1 infection using LC-MRM-MS with 3-nitrophenylhydrazine derivatization. J Pharm Biomed Anal. 20 Feb (2022); Vol 210: 114547. PubMed PMID: 35042145. DOI:  10.1016/j.jpba.2021.114547

   6. Chen YC, Figliozzi RW, Hsia SV. Pilot Analyses of Interferon Sub-type Expression Profiles in Patients with Herpes Zoster or Post Herpetic Neuralgia. Viral Immunology. Apr (2021); https://doi.org/10.1089/vim.2020.0295

   7. Fang C, Gujarati H, Osinaga F, Hsia SV, Cheney MA, Kharel MK. Optimization of the catalytic activity of manganese dioxide (MnO2) nanoparticles for degradation of environmental pollutants. Research on Chemical Intermediates (2021) https://doi.org/10.1007/s11164-021-04494-8

   8. Zhang Q, Martin-Caraballo, Hsia SV. Modulation of Voltage-Gated Sodium Channel (VGSC) Activity in Human Dorsal Root Ganglion (DRG) Neurons by Herpesvirus Quiescent Infection. J Virol. (2020) pii: JVI.01823-19. DOI: 10.1128/JVI.01823-19; PMID: 31694955

   9. Zhang Q, Martin-Caraballo, Hsia SV. Pathophysiological Roles and Therapeutic Potential of Voltage-gated Ion Channels (VGICs) in Pain Associated with Herpesvirus Infection. Cell & Bioscience (2020); DOI : 10.1186/s13578-020-00430-2

   10. Zhang Q, Hsia SV, Martin-Caraballo. Regulation of T-type Ca2+ channel expression by interleukin-6 in sensory-like ND7/23 cells post herpes simplex virus (HSV-1) infection. J Neurochemistry. (2019) Mar 19. doi: 10.1111/jnc.14697. PMID: 30888683

   11. Wong J. and Hsia SV. The expanding functions of thyroid hormone. Cell & Bioscience (2017) 7:53. DOI 10.1186/s13578-017-0176-0

   12. Figliozzi RW, Chen F, Hsia SV. Reversing thyroid hormone mediated repression of a HSV-1 promoter via computationally guided mutagenesis. Journal of Cell Sciences. (2017) Sep 15. doi: 10.1242/jcs.204222

   13. Zhang QJ, Hsia SV, and Martin-Caraballo MM. Regulation of T-type Ca2+ channel expression by herpes simplex virus-1 infection in sensory-like ND7 cells. Journal of Neuro Virology (2017), Oct. 23(5):657-670. doi: 10.1007/s13365-017-0545-9

   14. Hsia SV, Chen LH, and Tseng HF. Receipt of Thyroid Hormone Deficiency Treatment and Risk of Herpes Zoster. International Journal of Infectious Diseases (2017); Volume 59, June 2017, Pages 90–95. pii: S1201-9712(17)30127-3. doi: 10.1016/j.ijid.2017.04.016

   15. Figliozzi RW, Chen F, and Hsia SV. New Insights on Thyroid Hormone Mediated Regulation of Herpesvirus Infections. Cell & Bioscience (2017); March 21, 7:13. PubMed PMID: 28344765; PMCID: PMC5360088. https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-017-0140-z  

   16. Palem JR, Mudit M, Hsia SV, Sayed KA. Discovery and preliminary structure-activity relationship of the marine natural product manzamines as herpes simplex virus type-1 inhibitors. Zeitschrift für Naturforschung C (2017); doi: 10.1515/znc-2016-0080.

   17. Chen F., Figliozzi RW, Bedadala GR., Palem J, and Hsia SV. Overexpression of Thyroid Hormone Receptor β1 Altered Thyroid Hormone-Mediated Regulation of Herpes Simplex Virus-1 Replication in Differentiated Cells. Journal of Neuro Virology (2016); Volume 22, (5), p555-563; October; PMID: 26843385; DOI: 10.1007/s13365-016-0423-x

   18. Rochford K, Chen F, Waguespack Y, Figliozzi RW, Kharel MK, Zhang Q, Martin-Caraballo M, Hsia SV. Volatile Organic Compound Gamma-Butyrolactone Released upon Herpes Simplex Virus Type -1 Acute Infection Modulated Membrane Potential and Repressed Viral Infection in Human Neuron-Like Cells. PLoS One. (2016) Aug 18; 11(8): e0161119. doi: 10.1371/journal.pone.0161119. PubMed PMID: 27537375.

   19. Figliozzi RW, Chen F., Chi A., and Hsia, SV. Using Inverse Poisson’s Distribution to Calculate Multiplicity of Infection and Viral Replication by a High Throughput Fluorescent Imaging System. Virological Sinica (2016); PMID: 26826079, DOI: 10.1007/s12250-015-3662-8

   20. Ajavon A., Killian D., Odom R., Figliozzi R., Chen F., Balish M., Parmar J., Freeman R., Snitzer J., and Hsia SV. Influence of Thyroid Hormone Disruption on the Incidence of Shingles. Epidemiology and Infections Dec; 143 (16):3557-71. (2015); DOI: http://dx.doi.org/10.1017/S0950268815000655

   21. Figliozzi RW, Chen F, Balish MD, Ajavon A, and Hsia S. Thyroid Hormone-dependent Epigenetic Suppression of Herpes Simplex Virus-1 Gene Expression and Viral Replication in Differentiated Neuroendocrine Cells. Journal of Neurological Sciences (2014); http://dx.doi.org/10.1016/j.jns.2014.08.017 

   22. Hsia SH. and Hsia S. A Cohort Historical Analysis of the Relationship between Thyroid Hormone Malady and Alpha-Human Herpesvirus Activation. Journal of Steroids & Hormonal Science (2014); http://dx.doi.org/10.4172/2157-7536.1000133

   23. Chen F., Palem J., Balish M., Figliozzi R., Ajavon A., and Hsia S. A Novel Thyroid Hormone Mediated Regulation of HSV-1 Gene Expression and Replication is Specific to Neuronal Cells and Associated with Disruption of Chromatin Condensation. SOJ Pharmacy & Pharmaceutical Sciences (2014); PMID: 25346944 http://symbiosisonlinepublishing.com/pharmacy-pharmaceuticalsciences/pharmacy-pharmaceuticalsciences06.pdf 

   24. Bedadala G., Chen F., Figliozzi R., Balish M., and Hsia S. Construction and Characterization of Recombinant Hsv-1 Expressing Early Growth Response-1. ISRN Virology (2014); http://dx.doi.org/10.1155/2014/629641

   25. Hsia S., Graham LP., Bedadala GR., Balish MB., Chen F., and Figliozzi RW. Induction of Transcription Factor Early Growth Response Protein 1 during HSV-1 Infection Promotes Viral Replication in Corneal Cells. British Microbiology Research Journal (2013); http://dx.doi.org/ 10.9734/BMRJ/2013/4817 

   26. Hsia S., Parmar J., Freeman R, and Balish M. A Retrospective Cohort Analysis of the relationship between Thyroid Hormone Level and Herpes Simplex Virus-1 Activation. Health 5(8) 1201-1205 (2013); 10.4236/health.2013.58162

   27. Purohit AK., Balish MD., Leichty JJ., Roe A., Ward LM., Mitchell MO., and Hsia S. Antiviral activity and synthesis of quaternized proamzine derivatives against HSV-1. Bioorganic & Medicinal Chemistry 22; 5308–5312 (2012); http://dx.doi.org/10.1016/j.bmcl.2012.06.031

   28. Webre J., Hill JM., Clement C., Nolan N., McFerrin H., Bhattacharjee P, Hsia S., Neumann D., Lukiw WJ., Thompson HW., and Foster TP. Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases. Journal of Biomedicine and Biotechnology (2012); http://dx.doi.org/10.1155/S1110724301000018

   29. Hsia S, Bedadala GB, and Balish MD. Effects of thyroid hormone on HSV-1 gene regulation: implications in the control of viral latency and reactivation. Cell & Bioscience (2011); doi:10.1186/2045-3701-1-24

   30. Bedadala GR, Palem JR, Graham L, Hill JM, McFerrin HE, Hsia S. Lytic HSV-1 infection induces the multifunctional transcription factor Early Growth Response-1 (EGR-1) in rabbit corneal cells. Virology J. (2011), 8:262. PMID: 21619646; doi: 10.1186/1743-422X-8-262. 

   31. Palem JR., Bedadala GR., El Sayed K., and Hsia S. Development of Manzamine alkaloids as anti-viral agent to treat HSV-1 induced eye infections Planta Medica 76; 1-6 (2010). PMID: 20645244; doi: 10.1055/s-0030-1250093

   32. Bedadala GR., Pinnoji RC., Palem JR, and Hsia S. Role of Thyroid Hormone in The Gene Expression of HSV-1 LAT and ICP0 Cell Research, 20(5):587-98. (2010); PMID: 20386570; doi: 10.1038/cr.2010.50.

   33. Hsia S, Pinnoji RC., Bedadala GR., Hill JM., and Palem JR. Transcription Regulation of Herpes Simplex Virus Type 1 Thymidine Kinase by Thyroid Hormone Receptor Journal of Neuro Virology, 16(1):13-24. (2010) PMID: 20113192; doi: 10.3109/13550280903552412.

   34. Hsia S., Heimeier R., and Shi Y. Participation of BAF57 and BRG1-Containing Chromatin Remodeling Complexes in Thyroid Hormone-Dependent Gene Activation during Vertebrate Development. Mol. Endocrinol. (2008) 22(5):1065-77. Shared first author; doi: 10.1210/me.2007-0492. PMID: 18238828

   35. Pinnoji RC, Bedadala GR, George B, Holland TC, Hill JM, Hsia S.  Repressor Element-1 Silencing Transcription Factor/Neuronal Restrictive Silencer Factor (REST/NRSF) Can Regulate HSV-1 Immediate-Early Transcription via Histone Modification.  Virology J. Jun 7; 4(1):56 (2007). PMID: 17555596; PMC: PMC1906746; http://europepmc.org/articles/PMC1906746DOI: 10.1186/1743-422X-4-56

   36. Bedadala G., Pinnoji R., Hsia S. Early Gene Response Gene 1 (Egr-1) Regulates HSV-1 ICP4 and ICP22 Gene Expression.  Cell Research, 17 (5): 1-10 (2007). PMID: 17502875; DOI: 10.1038/cr.2007.44

   37. Hsia S.*, Buchholz D.*, Fu L., and Shi Y. A dominant negative thyroid hormone receptor blocks amphibian metamorphosis by retaining corepressors at target genes. Molecular and Cellular Biology 23 (19): 6750-6758 (2003) *share first author; PMID: 12972595. PMC: PMC193935; DOI: 10.1128/MCB.23.19.6750-6758.2003

   38. Hsia S., Tomita A., Obata K., Paul B., Buchholz D., and Shi Y. Role of chromatin disruption and histone acetylation in thyroid hormone receptor action: Implications in the regulation of HIV-1 LTR. Histology and Histopathology 18 (1): 323-331 (2003); PMID:12507309; URL: http://europepmc.org/abstract/med/12507309

   39. Hsia S., and Shi Y Chromatin disruption and histone acetylation in the regulation of HIV-1 LTR by thyroid hormone receptor. Molecular and Cellular Biology. 22 (12): 4043-4052 (2002). DOI: 10.1128/MCB.22.12.4043-4052.2002http://dx.doi.org/10.1128/MCB.22.12.4043-

   40. Hsia S., Wang H, and Shi Y. Involvement of Chromatin and Histone Acetylation in the Regulation of HIV-1 LTR by Thyroid Hormone Receptor. Cell Research 11(1), 8-16 (2001); DOI: 10.1038/sj.cr.7290061

   41. Shi Y., Fu L., Hsia S., Tomita A, Bucholz D., Thyroid hormone regulation of apototic tissue remodeling during anuran metamorphosis. Cell Research; 11(4): 245-52 (2001). DOI: 10.1038/sj.cr.7290093

   42. Sachs LM., Jones P., Hsia S., and Shi Y., Chromatin remodeling and developmental gene regulation by thyroid hormone receptor. Gene Therapy and Molecular Biology (5) 101-110 (2000); URL: http://gtmb.org/volumes/Vol5/10%20%20Sachs%20et%20al,%20101-110.pdf

   43. Hamouda T., McPhee R., Hsia S., Holland T. C., and King S. R. Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Replication by the Herpes Simplex Virus Type 1 (HSV-1) Virion Host Shutoff Protein. Journal of Virology 71: 5521-5527 (1997). PMID: 9188626; PMC: PMC191794. http://europepmc.org/articles/PMC191794 URL: http://europepmc.org/abstract/med/9188626